A Mediator Lost in the War on Cancer
نویسندگان
چکیده
An unexpected role for a Mediator subunit, MED12, in resistance to multiple anticancer agents is revealed by Huang et al. Loss of MED12 confers drug resistance by activating transforming growth factor b (TGF-b) signaling. Inhibition of the TGF-b pathway resensitizes cells to therapeutic drugs, suggesting a new combinatorial cancer treatment.
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ورودعنوان ژورنال:
- Cell
دوره 151 شماره
صفحات -
تاریخ انتشار 2012